Nature and Interactions of the Genetic Elements Governing Penicillinase Synthesis in Staphylococcus aureus

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Nature of the Determinant Controlling Penicillinase Production in Staphylococcus Aureus.

Harmon, Shirley A. (Ohio State University, Columbus), and Jack N. Baldwin. Nature of the determinant controlling penicillinase production in Staphylococcus aureus. J. Bacteriol. 87:593-597. 1964.-From three penicillinase-producing strains of Staphylococcus aureus 38 penicillin-sensitive mutants were isolated. With phages 80 and 53 of the International Typing Series, each of these mutants was a ...

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Regulation of penicillinase synthesis: a mutation in Staphylococcus aureus unlinked to the penicillinase plasmid that reduced penicillinase inducibility.

A mutant of Staphylococcus aureus strain 655 was isolated that is restricted in penicillinase induction. Wild-type plasmids that bear penicillinase determinants could not be fully induced in this mutant, 655par-1; hence, the responsible mutation is not located on the plasmid. Mutant plasmid PI(258)penI443, which produces penicillinase constitutively in wild-type cells, was fully constitutive fo...

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Stability of penicillinase plasmids in Staphylococcus aureus.

The isolation of mutants of Staphylococcus aureus that are affected in the stability of penicillinase plasmids is described. One mutation is plasmid borne and results in nonreplication of the plasmid at 42 C. A second type of mutation is host-borne and gives rise to instability of both mcr(I) and mcr(II) penicillinase plasmids but not a tetracycline-resistant plasmid.

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Regulation of Penicillinase Synthesis : a Mutation in Staphylococcus aureus Unlinked to the Penicillinase Plasmid That Reduces Penicillinase Inducibility

A mutant of Staphylococcus aureus strain 655 was isolated that is restricted in penicillinase induction. Wild-type plasmids that bear penicillinase determinants could not be fully induced in this mutant, 655par-1; hence, the responsible mutation is not located on the plasmid. Mutant plasmid PI258 penI443, which produces penicillinase constitutively in wild-type cells, was fully constitutive for...

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Naturally occurring penicillinase plasmids in Staphylococcus aureus.

A series of plasmids harbored by naturally occurring penicillin-resistant strains of Staphylococcus aureus were surveyed with a view toward exploring the variability in plasmid-linked marker patterns. Plasmids were transduced from their natural hosts to either of two plasmid-negative laboratory strains by selection for cadmium resistance, and the transductants were tested for all other markers ...

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 1965

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.90.2.467-480.1965